An extensive research review of existing scientific findings involving bioactive compounds in Ganoderma Lucidum and the physiological effects of these compounds.
The present invention relates to a method for preparing Ganoderma spore oil which is in the field of biotechnology. The method includes using Ganoderma spore powder and Ganoderma powder (obtained from grinding fruiting bodies) as raw materials, applying enzymatic Ganoderma sporoderm broken methods, one-step granulation, supercritical CO2 extraction method, as well as centrifugation and refining. The light yellow oleaginous substances obtained posses a variety of physiological functions such as strengthening immunity, protecting the liver and inhibiting tumor cell growth, etc. Ganoderma spore oil prepared with the present technology contains not only spore extracts, but also extracts from Ganoderma fruiting bodies and mycelium by CO2 supercritical extraction, with more types of triterpenoids. The inhibitory effects of Ganoderma spore oil is a onefold higher than spore oil prepared from the physical preparation of the sporoderm-broken spore. Meanwhile, the problem of spore oil spoilage arising from oxidation is solved due to the low peroxide value within Ganoderma spore oil, and thereby the quality of Ganoderma spore oil is greatly improved.
Enclosed abstract from (Front. Pharmacol., 26 March 2019 (https://doi.org/10.3389/fphar.2019.00272) (1)
Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer’s Disease by Regulating DNA Methylation in Rodents
Guoxiao Lai1,2†, Yinrui Guo2†, Diling Chen2*, Xiaocui Tang2, Ou Shuai2, Tianqiao Yong2, Dongdong Wang2, Chun Xiao2, Gailian Zhou1, Yizhen Xie2*, Burton B. Yang2,3 and Qingping Wu2
1College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China
2State Key Laboratory of Applied Microbiology Southern China – Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application – Guangdong Open Laboratory of Applied Microbiology – Guangdong Institute of Microbiology, Guangzhou, China
3Institute of Medical Science, University of Toronto, Toronto, ON, Canada
“… Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system disorders, including Alzheimer’s disease (AD), in elderly individuals; hence, modulation of these methylation changes may be an effective strategy to delay the progression of AD pathology…. “Auxiliary tests also demonstrated that G. lucidum alcohol extracts could improve learning and memory function, ameliorate neuronal apoptosis and brain atrophy, and down-regulate the expression of the AD intracellular marker, Aβ1-42. We concluded that alcohol extracts from G. lucidum, including ganoderic acid and lucidone A, are the main extracts involved in delaying AD progression…”(1)