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Inhibitory Effect of Five Ganoderma Species against Key Digestive Enzymes Related to Type 2 Diabetes
Jan 19, 2021

Article Details

Author(s): Shao-Dan Chen 1, Tian-Qiao Yong 1, Yi-Fan Zhang 1, Hui-Ping Hu 1, Yi-Zhen Xie 2

Research Journal: International Journal of Medicinal Mushrooms, Volume 21, Article number: 7, pages 703-711

Year of Publication: 2019

Article Link: https://pubmed.ncbi.nlm.nih.gov/31679304/


What is this research article about?

Researchers investigated the antidiabetic effect of five species of Ganoderma.

What are the main research findings?

Between the two main bioactive compounds within Ganoderma, triterpenoids had a greater effect on anti-α-glucosidase and anti-α-amylase activity - compared with polysaccharides.

Among the five species of Ganoderma tested, Ganoderma Lucidum triterpenoids had the most significant inhibitory effect on α-glucosidase and α-amylase activity.

ⓘ α-glucosidase and α-amylase are key enzymes involved in our digestion of carbohydrates. Inhibiting activity of these enzymes help to reduce spikes in blood sugar after a meal – an important strategy in control blood sugar levels.


Research Article Abstract

Ganoderma mushrooms are widely used in clinical therapies and functional foods. The antidiabetic effect of Ganoderma has become a research hot spot in recent decades. To search for a superior antidiabetic Ganoderma extract, five common Ganoderma species (G. lucidum, G. sinense, G. tsugae, G. applanatum, and G. leucocontextum) were investigated. A total of 10 fractions, including a total triterpenes fraction and a crude polysaccharides fraction for each, were prepared for further assays. Activities of α-glucosidase and α-amylase are inhibited dominantly by triterpenes from all five Ganoderma species rather than the polysaccharides. G. lucidum triterpenes inhibits α-glucosidase and α-amylase most significantly with IC50 values of 10.02 ± 0.95 µg/mL and 31.82 ± 4.30 µg/mL. Even more, triterpenes content was positively correlated with anti-α-glucosidase and anti-α-amylase activities. Therefore, triterpenes were considered to be the active compounds in inhibiting α-glucosidase and α-amylase activity. It is hoped that the results will provide more systematic information for the application of Ganoderma in the functional food and traditional medicine industries in the future.


  • 1State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China; Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, 510070, China.
  • 2Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou, P.R. China; Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, P.R. China.
Chen, S.-D., Yong, T.-Q., Zhang, Y., Hu, H.-P., & Xie, Y.-Z. (2019). Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus. International Journal of Medicinal Mushrooms, 21(7), 703–711. Retrieved from https://doi.org/10.1615/IntJMedMushrooms.v21.i7.70
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