Anti-Inflammatory

An extensive research review of existing scientific findings involving bioactive compounds in Ganoderma Lucidum and the physiological effects of these compounds.

The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation

Chunwei Jiao,^1,2,3 Yizhen Xie,^2,3 Hao Yun,² Huijia Liang,² Chunyan He,² Aimin Jiang,¹ Qingping Wu,³ and Burton B. Yang^4,5

Skin is the body’s largest and most exposed organ. It is the first line of the body’s immunological defense against various forms of attack from external environment [1]. Following skin injury, an organism needs to rapidly restore itself to avoid dehydration, blood loss and the entrance of harmful microorganisms [2]. Burns damage the skin extensively and have been studied for centuries, with thermal burns from dry sources (fire or flame) or wet sources (scalds) accounting for approximately 80% of all reported burn injuries [3]. Approximately 180,000 deaths annually are caused by burns; the vast majority occur in low- and middle-income countries [4]. Severe burn injury leads to a clear systemic inflammatory response that has been reported in human subjects [5, 6]. However, low public hygiene measures in low- and middle-income countries might lead to secondary bacterial infections. Therefore, antibiotics (ANT) for an anti-inflammatory effect are needed. Unfortunately, increased microbial drug resistance is being caused by widespread ANT use, leading to poor treatment efficacy in burn wound healing. Moreover, scar tissue formation after burn injury can also lead to long-term psychosocial consequences [7]. Therefore, effective and healthy treatments for burn wound healing are necessary for clinical therapy....

Abstract

Inventor

Yizheng Xie, Shenzhu Li, Burton B. Yang, Chong Li, Zhi Zhang, Qingping Wu, Guanzhou Chen, Biao Luo