An extensive research review of existing scientific findings involving bioactive compounds in Ganoderma Lucidum and the physiological effects of these compounds.
The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation
Skin is the body’s largest and most exposed organ. It is the first line of the body’s immunological defense against various forms of attack from external environment . Following skin injury, an organism needs to rapidly restore itself to avoid dehydration, blood loss and the entrance of harmful microorganisms . Burns damage the skin extensively and have been studied for centuries, with thermal burns from dry sources (fire or flame) or wet sources (scalds) accounting for approximately 80% of all reported burn injuries . Approximately 180,000 deaths annually are caused by burns; the vast majority occur in low- and middle-income countries . Severe burn injury leads to a clear systemic inflammatory response that has been reported in human subjects [5, 6]. However, low public hygiene measures in low- and middle-income countries might lead to secondary bacterial infections. Therefore, antibiotics (ANT) for an anti-inflammatory effect are needed. Unfortunately, increased microbial drug resistance is being caused by widespread ANT use, leading to poor treatment efficacy in burn wound healing. Moreover, scar tissue formation after burn injury can also lead to long-term psychosocial consequences . Therefore, effective and healthy treatments for burn wound healing are necessary for clinical therapy....
The present invention relates to a method for preparing Ganoderma spore oil which is in the field of biotechnology. The method includes using Ganoderma spore powder and Ganoderma powder (obtained from grinding fruiting bodies) as raw materials, applying enzymatic Ganoderma sporoderm broken methods, one-step granulation, supercritical CO2 extraction method, as well as centrifugation and refining. The light yellow oleaginous substances obtained posses a variety of physiological functions such as strengthening immunity, protecting the liver and inhibiting tumor cell growth, etc. Ganoderma spore oil prepared with the present technology contains not only spore extracts, but also extracts from Ganoderma fruiting bodies and mycelium by CO2 supercritical extraction, with more types of triterpenoids. The inhibitory effects of Ganoderma spore oil is a onefold higher than spore oil prepared from the physical preparation of the sporoderm-broken spore. Meanwhile, the problem of spore oil spoilage arising from oxidation is solved due to the low peroxide value within Ganoderma spore oil, and thereby the quality of Ganoderma spore oil is greatly improved.